What should I avoid while taking salvestrols?

The CYP1B1 enzyme can react with many different substances aside from Salvestrols. The life cycle of the enzyme is about 3 days (that is, each molecule of CYP1B1 is replaced by a new one roughly every three days).

Some substances inhibit the CYP1B1 enzyme. Once an inhibitory substance reacts with the enzyme it is prevented from metabolising and activating Salvestrols. If inhibitors are present in your body, they will compete with salvestrols to react with the CYP1B1 enzyme. The competition will depend, in part, on the relative levels of both the inhibitors and the salvestrols and their affinity for CYP1B1.

The inhibition from some inhibitors will last the full life cycle of the enzyme. It is important to reduce or eliminate exposure to inhibitors to give Salvestrols their best chance of being activated. Strong inhibitors of CYP1B1 include carbon monoxide (e.g. in tobacco smoke), vitamin B17 (also known as amygdalin or laetrile), resveratrol, and certain agrochemical fungicides.

Agrochemical fungicides are doubly problematic. When used on crops they impair the plant's production of salvestrols. The plants will only produce the salvestrols in abundance when under attack from pathogens. But, in addition, inside the body these same fungicides can inhibit the metabolic activity of the CYP1B1 enzyme in the same way as does Vitamin B17, i.e., binding with the enzyme in a benign manner and thus reducing or eliminating the metabolism of salvestrols.

As a further complication, agrochemical fungicides are used in agriculture but are also found elsewhere which makes their avoidance difficult. Fungicides can be used on golf courses, public park areas, in new carpeting, dandruff shampoos, house paints and can be added to the cleaning agents used when heating ductwork is cleaned.